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Monday, May 4, 2020 | History

3 edition of Mechanisms of Cell Toxicity (Advances in Molecular and Cell Biology) found in the catalog.

Mechanisms of Cell Toxicity (Advances in Molecular and Cell Biology)

  • 249 Want to read
  • 16 Currently reading

Published by JAI Press .
Written in English

    Subjects:
  • Cellular biology,
  • Haematology,
  • Molecular Biology,
  • Cytology,
  • Science/Mathematics

  • The Physical Object
    FormatHardcover
    Number of Pages254
    ID Numbers
    Open LibraryOL10908609M
    ISBN 100762301414
    ISBN 109780762301416

    Nanotoxicology and anticancer nanotherapeutics are essentially two sides of the same coin. The nanotoxicology discipline deals with the nanoparticle (NP)-induced toxicity and mechanisms of cell death in healthy cells, whereas anticancer agents delivered via nano-based approaches aim to induce cell death in abnormally proliferating cancer : Shalini Minocha. This book illustrates the chemistry, toxicology, and health effects of arsenic using novel modeling techniques, case studies, experimental data, and future perspectives. Covers exposure sources, health risks, and mechanisms of one of the most toxic minerals in the world Helps readers understand potential health effects of arsenic, using population studies, mammalian and invertebrate models.


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Mechanisms of Cell Toxicity (Advances in Molecular and Cell Biology) by J. Kevin Chipman Download PDF EPUB FB2

Purchase Mechanisms of Cell Toxicity, Volume 20 - 1st Edition. Print Book & E-Book. ISBNThe most complex path to toxicity involves more steps (Figure 3–1).First, the toxicant is delivered to its target or targets (step 1), interacting with endogenous target molecules (step 2a) or altering the environment (step 2b), triggering perturbations in cell function and/or structure (step 3), which initiate repair mechanisms at the molecular, cellular, and/or tissue levels (step 4).

Search in this book series. Mechanisms of Cell Toxicity. Edited by E. Edward Bittar. Vol Pages iii-xiii, () Download full volume. Previous volume. Reactive Oxygen Species and their Cytotoxic Mechanisms. M.D. Evans, H.R. Griffiths, J. Lunec. Pages Download PDF. The mechanisms of cell toxicity are widely involved.

It has long been proved that toxicant may induce overproduction of Nitric oxide (NO), reactive oxygen species (ROS) and the subsequent oxidative stress. The high level of NO, ROS and the subsequent oxidative burst have been identified as one main mechanism of severe cell toxicity or even Cited by: 8.

First Published in Written by specialists in their fields, this book contains short reviews intended to highlight points of growing interest in mechanistic toxicology.

The first section considers selected aspects of molecular mechanisms, including selectivity of toxic agents and repair processes in the nervous system, toxicity of oxygen. Obviously, the cell is not a passive victim of a toxic insult but is able to initiate well defined reactions in response to damage.

This can contribute greatly to the characteristic properties of toxic substances, such as organ selectivity. An understanding of the intracellular regulation of cell death is therefore imperative. Lee JY., Tokumoto M., Satoh M.

() Novel Mechanisms of Cadmium-Induced Toxicity in Renal Cells. In: Himeno S., Aoshima K. (eds) Cadmium Toxicity. Current Topics in Environmental Health and Preventive : Jin-Yong Lee, Maki Tokumoto, Masahiko Satoh.

Mechanisms of cell toxicity and in vitro toxicology Cell Toxicity. The dose “makes” the poison "dosis sola facit venenum" - dosage alone makes the poison. Dose-response curves Dose (at target tissue) Might be able to identify chemicals common mechanisms of action – e.g.

genotoxins, enzyme inducers etc. Approaches - fluorescent. Mechanisms of Cytotoxicity by NK Cells is the resulting book of a workshop focused on the studies that enhance understanding of the basic mechanisms involved in the function and regulation of NK cells.

The book presents the status of knowledge of the mechanisms responsible for the cytotoxic effects of NK cells and the regulation of their activity. MTT Tetrazolium Assay Concept. The MTT (3-(4,5-dimethylthiazolyl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction assay was the first homogeneous cell viability assay developed for a well format that was suitable for high throughput screening ().The MTT tetrazolium assay technology has been widely adopted and remains popular in academic labs as evidenced by Cited by:   Mechanisms Of Viral Toxicity In Animal Cells.

DOI link for Mechanisms Of Viral Toxicity In Animal Cells. Mechanisms Of Viral Toxicity In Animal Cells book. By Luis Carrasco. Edition 1st Edition. First Published eBook Published 18 January Mechanisms of Virus-Induced Cell Toxicity: A General Overview. With L. Carrasco Cited by:   There are several other examples of interference with physiological cell signaling by foreign chemicals, and more will probably follow.

Hence, it is important to continue the work to unravel remaining secrets of cell death signaling in order to further our understanding of toxicity mechanisms and improve risk by: Mechanisms of alcohol toxicity.

associated with alcohol consumption are particularly discussed to provide insight into the molecular basis of hepatic cell dysfunction and destruction as well. Toxicity is commonly interpreted as alterations in normal cellular physiology, biochemistry, and morphology, leading to cell injury and in the extreme cell death.

Mechanisms of cell toxicity. Toxic insult and manipulation of cell signalling and control mechanisms in cell growth and differentation also highlight how important the discipline of cell toxicity has been and will continue to be a major contributor to our understanding of basic issues in the biological and biomedical sciences.

This book. Page 7 Mechanisms of Toxicity. In this chapter, the subcommittee summarizes what is known about the mechanisms of toxicity for arsenic. The chapter is divided into two major sections-cancer and noncancer effects.

The First International Workshop on Mechanisms in Cell-Mediated Cytoxicity was held at Carry-Ie-Rouet, France, SeptemberThe Workshop brought together for the first time leading investiga­ tors in each of the principal areas of cell-mediated cytotoxicity, as well as experts in the area of complement-mediated cytoxicity.

Mechanisms of cell uptake and toxicity of the anticancer drug cisplatin Two major issues which hamper the use of the anticancer drug cisplatin are the development of cancer cell resistance and its nephrotoxicity.

One possible mechanism by which resistance is reported to develop is a reduction in drug uptake across the cell membrane. Cytotoxic T lymphocytes (CTLs) are generated by immune activation of cytotoxic T cells (Tc cells).

They are generally CD8+, which makes them MHC class I restricted. CTLs are able to. This Research Topic on "Death mechanisms, and toxicity" will be devoted to scientific excellence in the field of cancer cell death and survival mechanisms.

The most relevant topics will be cell death mechanisms (such as apoptosis) non-apoptotic cell death mechanisms (including but not limited to autophagy, necroptosis, ferroptosis, methuosis. Mn tolerance mechanisms include activation of the antioxidant system, regulation of Mn uptake and homeostasis, and compartmentalization of Mn into subcellular compartments (e.g., vacuoles, endoplasmic reticulum, Golgi apparatus, and cell walls).

In this regard, numerous genes are involved in specific pathways controlling Mn : Jifu Li, Yidan Jia, Rongshu Dong, Rui Huang, Pandao Liu, Xinyong Li, Zhiyong Wang, Guodao Liu, Zhiji. Get this from a library.

Mechanisms of viral toxicity in animal cells. [Luis Carrasco;] -- "The present book is intended to give an account of the state of the art on how animal viruses induce cytotoxic effects in cells."--Provided by publisher.

This chapter will highlight on the various sources of heavy metals and the processes that promote their exposure and bioaccumulation in the human body.

More focus will be laid on the various mechanisms that lead to heavy metal toxicity with emphasis on macromolecule and cellular damages, carcinogenesis, neurotoxicity and the molecular basis for Cited by: 6.

Selective toxicity antimicrobials are easier to develop against bacteria because they are _____ cells, whereas human cells are eukaryotic. Prokaryotic Antiviral drugs, like Tamiflu and Relenza, that are effective against the influenza virus by preventing viral escape from host cells are called ________.

CHE induced cell apoptosis through ROS-mediated ER stress in PC-3 cells Conclusion References. Programmed cell death mechanisms and nanoparticles toxicity Molecular mechanisms underlying nanomaterials toxicity Major forms of programmed cell death More than one way to skin a cat Programmed cell death: ApoptosisBook Edition: 1.

The First International Workshop on Mechanisms in Cell-Mediated Cytoxicity was held at Carry-Ie-Rouet, France, SeptemberThe Workshop brought together for the first time leading investiga­ tors in each of the principal areas of cell-mediated cytotoxicity, as well as experts in the area of complement-mediated : Paperback.

Antifungal agents: mechanisms of action Frank C. Odds, Alistair J.P. Brown and Neil A.R. Gow Aberdeen Fungal Group, University of Aberdeen, Department of Molecular and Cell Biology, Institute of Medical Sciences, Aberdeen AB25 2ZD, UK Clinical needs for novel antifungal agents have altered steadily with the rise and fall of AIDS-related mycoses,File Size: 2MB.

derstanding the mechanisms underlying chemically induced developmental defects. Perhaps the most influential review and assessment of the state of knowledge published in that expansionary phase of teratology was J.G.

Wilson’s landmark book Environment and Birth Defects (). To this day, Wilson’s book is useful as a summary of the principles of teratogenesis (described below) that were. 13 Mechanisms of Cell Death Mac Law and Susan Elmore. Introduction How Cells/Tissues React to “Stress” Cell Injury and Cell Death Morphology of Cell Injury and Cell Death Apoptosis, Morphology, and Mechanisms Other Cell Death Modalities Acknowledgments Reference This volume provides an up-to-date review of the molecular mechanisms of toxicity.

Individual chapters deal with specific aspects of toxicity problems associated with selected organs. Contains a review of contemporary knowledge of the molecular mechanisms of toxicity as applied to various organsContrasts with other volumes in dealing with the mechanistic approach to the subjectDiscusses.

Specific topics discussed include NK cell receptors and adhesion molecules, signal transduction and activation, and mechanisms of cytotoxicity. The book will be an excellent learning tool and reference resource for scientists, clinicians, and students. As the field of nanomedicine emerges, there is a lag in research surrounding the topic of nanoparticle (NP) toxicity, particularly concerned with mechanisms of action.

The continuous emergence of bacterial resistance has challenged the research community to develop novel antibiotic agents. Metal NPs are among the most promising of these because show strong antibacterial by: Extensively illustrated, this book forms a conceptual bridge between multiple events at the molecular level and the determinants of toxicity at the physiological and cellular level.

Specific examples of drugs, environmental pollutants, and other chemicals are carefully chosen to illustrate and highlight the fundamental mechanisms of toxicity at.

Gallotannin has been shown to induce programmed cell death in a wide variety of cancers including colon, breast, prostate, and liver, among others. Apoptosis, cellular senescence, autophagy, and necrosis are the main mechanisms by which GT can suppress cancer progression. In addition, GT is a potent inhibitor of many proliferation : Marwa Houssein, Hala Gali-Muhtasib.

Nk Cell Mediated Cytotoxicity: Receptors, Signaling, and Mechanisms 1st Edition by Eva Lotzova (Author) ISBN ISBN Why is ISBN important. ISBN.

This bar-code number lets you verify that you're getting exactly the right version or edition of a book. Cited by:   T1 - Molecular mechanisms of amyloid oligomers toxicity. AU - Kayed, Rakez. AU - Lasagna-Reeves, Cristian A. PY - /12/1. Y1 - /12/1. N2 - Amyloid oligomers have emerged as the most toxic species of amyloid-β (Aβ).

This hypothesis might explain the lack of correlation between amyloid plaques and memory impairment or cellular by: The regulation of translation in eukaryotic cells plays an important part in gene expression.

Two types of regulation of translation occur: the unspecific regulation that occurs when translation of all cellular mRNAs increases or decreases after a given stimulus, and the specific regulation when protein synthesis directed by some messenger ribonucleic acid (mRNAs) by: An understanding of the mechanisms of toxicity is of both practical and theoretical importance.

Such information provides a rational basis for interpreting descriptive toxicity data, estimating the probability that a chemical will cause harmful effects, establishing procedures to prevent or antagonize the toxic effects, designing drugs and industrial chemicals that are less hazardous, and.

Mammalian Toxicology surveys chemical agents and examines how such chemicals impact on human health, emphasizing the importance in minimizing environmental exposure to chemical and physical hazards in our homes, communities and workplaces through such media as contaminated water, soil and air.

Starting with the basic principles on a wide range of toxic agents, this textbook describes how they. Topics covered include the role of metabolism in mediating toxicity, molecular mechanisms of cell injury/cell death, approaches for estimating human exposure to toxic chemicals, and the known roles of toxic chemicals in human target organ toxicity.

Evaluating toxicity mechanisms using DNA. These ideas are explored in detail in a book titled Toxicogenomics-Based Cellular Models: Alternatives to Animal Testing for Safety book Author: Roshan Kumar Sahu, Kamal Kishor.Nevertheless, the precise mechanisms of toxicity remain unknown. To achieve safe utilization of NPs, more studies must be performed.

The toxicity mechanisms of CuO and ZnO NPs may be mainly dependent on the interaction between NPs and biomolecules, and toxicity mainly involves protein unfolding [ 98 ], fibrillation, thiol cross-linking, and Cited by: @article{osti_, title = {Mechanisms of nitrogen dioxide toxicity in humans}, author = {Utell, M J and Frampton, M W and Roberts, Jr, N J and Finkelstein, J N and Cox, C and Morrow, P E}, abstractNote = {These studies were undertaken to evaluate short-term respiratory effects and identify markers of nitrogen dioxide toxicity during exposures designed to approximate realistic conditions.